Publications

  1. N.R. Latorraca, S. Sabaat, C.H. Habrian, J. Bleier, C. Stanley, C.D. Kinz-Thompson, S. Marqusee, E.Y. Isacoff. Domain coupling in activation of a family C GPCR. Nat Chem. Biol. (2025).

  2. A.S. Powers, A. Khan, J.M. Paggi, N.R. Latorraca, S. Souza, J. Di Salvo, J. Lu, S.M. Soisson, J.M. Johnston, A.B. Weinglass, R.O. Dror. A non-canonical mechanism of GPCR activation. Nat Commun 15, 9938 (2024).

  3. K. K. Kumar, H. Wang, C. Habrian, N.R. Latorraca, J. Xu, E.S. O'Brien, C. Zhang, E. Montabana, A. Koehl, S. Marqusee, E.Y. Isacoff, B.K. Kobilka. Step-wise activation of a metabotropic glutamate receptor. Nature. 629, 951–956 (2024).

  4. C. Habrian, N.R. Latorraca, Z. Fu, E.Y. Isacoff. Homo- and hetero-dimeric subunit interactions set affinity and efficacy in metabotropic glutamate receptors. Nat. Comm. 14, 8288 (2023).

  5. K. K. Kumar, E. S. O'Brien, C. Habrian, N.R. Latorraca, H. Wang, I. Tuneew, E. Montabana, S. Marqusee, D. Hilger, E.Y. Isacoff, J. M. Mathiesen, B.K. Kobilka Negative allosteric modulation of the glucagon receptor by RAMP2. Cell 186(7): 1465-1477 (2023).

  6. F. Hidalgo, L.M. Nocka, N.H. Shah, K. Gorday, N.R. Latorraca, P. Bandaru, S. Templeton, D. Lee, D. Karandur, J. G. Pelton, S. Marqusee, D.E. Wemmer, J. Kuriyan. A Saturation-Mutagenesis Analysis of the Interplay Between Stability and Activation in Ras. eLife 11:e76595 (2022).

  7. C.M. Lemon, A.J. Nissley, N.R. Latorraca, E.C. Wittenhorn, M.A. Marletta. Exploring Corrole–Protein Interactions in H-NOX and HasA. RSC Chem. Biol. 3, 571 (2022).

  8. E.C. Carroll†, N.R. Latorraca†, J.M. Lindner, B.C. Maguire, J.G. Pelton, and S. Marqusee. Mechanistic basis for ubiquitin modulation of a protein energy landscape. PNAS 118 (12) e2025126118. (2021).

  9. C.-M. Suomivuori†, N.R. Latorraca†, L.M. Wingler, S. Eismann, M.C. King, A.W. Kleinhenz, M.A. Skiba, D.P. Staus, A.C. Kruse, R.J. Lefkowitz, and R.O. Dror. Molecular mechanism of biased signaling in a prototypical G protein–coupled receptor. Science 367(6480):881-887 (2020).

  10. N.R. Latorraca†, M. Masureel†, S.A. Hollingsworth, F.M. Heydenreich, C.-M. Suomivuori, C. Brinton, R.J.L. Townshend, M. Bouvier, B.K. Kobilka, and R.O. Dror. How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling. Cell 183(7):1813-1825 (2020).

  11. L.M. Wingler, M.A. Skiba, C. McMahon, D.P. Staus, A.W. Kleinhenz, C.-M. Suomivuori, N.R. Latorraca, R.O. Dror., R.J. Lefkowitz, and A.C. Kruse. Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR. Science 367(6480):888-892 (2020)

  12. E.M. Jones, N.B. Lubock, A.J. Venkatakrishnan, J. Wang, A.M. Tseng, J.M. Paggi, N.R. Latorraca, D. Cancilla, M. Satyadi, J.E. Davis, M.M. Babu, R.O. Dror, and S. Kosuri. Structural and Functional Characterization of G Protein-Coupled Receptors with Deep Mutational Scanning. eLife (2020).

  13. T.A. Chew, B.J. Orlando, J. Zhang, N.R. Latorraca, A. Wang, S.A. Hollingsworth, D.H. Chen, R.O. Dror, M. Liao and L. Feng. Structure and mechanism of the cation–chloride cotransporter NKCC1. Nature 572:488–492 (2019). 

  14. H.E. Kato, Y. Zhang, H. Hu, C.-M. Suomivuori, F.M.N. Kadji, J. Aoki, K.K. Kumar, R. Fonseca, D. Hilger, W. Huang, N. R. Latorraca, A. Inoue, R.O. Dror, B.K. Kobilka and G. Skiniotis. Conformational transitions of a neurotensin receptor 1–Gi1 complex. Nature 572:80–85 (2019). 

  15. I. Deshpande, J. Liang, D. Hedeen, K.J. Roberts, Y. Zhang, B. Ha, N.R. Latorraca, B. Faust, R.O. Dror, P.A. Beachy, B.R. Myers and A. Manglik. Smoothened stimulation by membrane sterols drives Hedgehog pathway activity. Nature 571:284–288 (2019). 

  16. A.J. Venkatakrishnan, A. Ma, R. Fonseca, N.R. Latorraca, B. Kelly, R. Betz, C. Asawa, B. Kobilka, and R.O. Dror. Diverse GPCRs exhibit conserved water networks for stabilization and activation. PNAS 116(8):3288-3293 (2019). 

  17. L.M. Wingler, E. Matthias, D. Hilger, N.R. Latorraca, M.T. Lerch, D.P. Staus, R.O. Dror, B.K. Kobilka, W.L. Hubbell, and R.J. Lefkowitz. Angiotensin analogs with divergent bias stabilize distinct receptor conformations. Cell 176(3):468-478 (2019). 

  18. K.K. Kumar, M. Shalev-Benami, M.J. Robertson, H. Hu, S.D. Banister, S.A. Hollingsworth, N.R. Latorraca, H.E. Kato, D. Hilger, S. Maeda, W.I. Weis, D.L. Farrens, R.O. Dror, S.V. Malhotra, B.K. Kobilka, and G. Skiniotis. Structure of a signaling cannabinoid receptor 1-G protein complex. Cell 176(3):448–458 (2019).

  19. H.Q. Nguyen, J. Roy, B. Harink, N.P. Damle, N.R. Latorraca., B.C. Baxter, K. Brower, S. Longwell, T. Kortemme, K.S. Thorn, M.S. Cyert, and P.M. Fordyce. Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads. eLife 8 (2019).

  20. N.R. Latorraca, J. K. Wang, B. Bauer, S. A. Hollingsworth, J. Olivieri, M. E. Sommer and R. Dror. Molecular mechanism of GPCR-mediated arrestin activation. Nature. 557: 452-456 (2018).

  21. K. Eichel, D. Jullié, B. Barsi-Rhyne, N.R. Latorraca, M. Masureel, J. Sibarita, R.O. Dror, and M. von Zastrow. Catalytic activation of β-arrestin by GPCRs. Nature. 557: 381-386. 2018.

  22. A. Koehl, H. Hu, S. Maeda, Y. Zhang, Q. Qu, J.M. Paggi, N.R. Latorraca, D. Hilger, R. Dawson, H. Matile, G.F.X. Schertler, S. Granier, W.I. Weis, R.O. Dror, A. Manglik, G. Skiniotis, B.K. Kobilka. Structure of the μ opioid receptor-Gi protein complex. Nature. 558: 547-552 (2018).

  23. N. Van Eps, C. Altenbach, L.N. Caro, N.R. Latorraca, S.A. Hollingsworth, R.O. Dror, O.P. Ernst, and W.L. Hubbell. Gi- and Gs-coupled GPCRs show different modes of G protein binding. PNAS. 115(10):2383-2388 (2018).

  24. N.R. Latorraca†, N.M. Fastman†, A.J. Venkatakrishnan, W.B. Frommer, R.O. Dror, and L. Feng. Mechanism of substrate translocation in an alternating access transporter. Cell. 169(1):96-107 (2017).

  25. X. Liu, S. Ahn, A.W. Kahsai, K.C. Meng, N.R. Latorraca, B. Pani, A.J. Venkatakrishnan, A. Masoudi, W.I. Weis, R.O. Dror, X. Chen, R.J. Lefkowitz, and B.K. Kobilka. Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature 548: 480-484 (2017).

  26. X.E. Zhou, Y. He, P.W. de Waal, X. Gao, Y. Kang, N. Van Eps, Y. Yin, K. Pal, D. Goswami, T.A. White, A. Barty, N.R. Latorraca, H.N. Chapman, W.L. Hubbell, R.O. Dror, R.C. Stevens, V. Cherezov, V.V. Gurevich, P.R. Griffin, O.P. Ernst, K. Melcher, and H.E. Xu. Identification of phosphorylation codes for arrestin recruitment by G protein-coupled receptors. Cell 170: 457-469 (2017).

  27. N.R. Latorraca, A.J. Venkatakrishnan, and R.O. Dror. GPCR dynamics: structures in motion. Chem Rev. 117(1)139-155 (2017).

  28. S. Hertig, N.R. Latorraca, and R.O. Dror. Revealing atomic-level mechanisms of protein allostery with molecular dynamics simulation. PLoS Comp Bio. 12(6):e1004746 (2016).  

  29. N.R. Latorraca†, K.M. Callenberg†, J.P. Boyle and M. Grabe. Continuum approaches to understanding ion and peptide interactions with the membrane. J Membr Biol. 247(5):395-408 (2014).

  30. K.M. Callenberg, N.R. Latorraca, and M. Grabe. Membrane bending is critical for the stability of voltage sensor segments in the membrane. J Gen Physiol. 140:55-68 (2012).

† denotes co-first authorship